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KMID : 0811720030070000189
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Korean Journal of Physiology & Pharmacology
2003 Volume.7 No. 0 p.189 ~ p.0
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Mepacrine Reduces Serum Ferritin Increases and Acute Lung Injury in Rats Subjected to Severe Hemorrhage
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Park Yoon-Yub
Kim Teo-An
Lee Young-Man
John E Repine
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Abstract
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Hemorrhagic shock and trauma are two of the most common causes of acute lung injury (ALI). For unknown reasons, serum ferritin levels are increased in patients at-risk for and with ALI and multiple organ failure (MOF). Ferritin is important in regulating free iron (Fe++) levels and free iron could enhance the toxicity of the increased oxidative stress that occurs in ALI and MOF patients. This study investigated the changes of ferritin on severe-hemorrhage induced acute lung injury in Sprague-Dawley rats. The hemorrhagic shock was induced by withdrawing blood through the femoral artery at a constant rate of 4 ml/kg/min for 5 minutes (total 20 ml/kg). In the present investigation, we found that serum and lung lavage ferritin levels increased in hemorrhaged rats that develop acute lung injury. Treatment with mepacrine (60 mg/kg), a putative phospholipase A₂ inhibitor, not only decreased serum and lavage ferritin increases but also increases in lung lavage white blood cell counts, myeloperoxidase activities and protein concentrations that occurred in rats subjected to hemorrhage. Serum ferritin increases are associated with the development of ALI in hemorrhaged rats and mepacrine is an effective pretreatment way of decreasing serum ferritin increases and acute lung injury in hemorrhaged rats.
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KEYWORD
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Acute lung injury, Ferritin, Hemorrhage, Mepacrine
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